Oxidative Phosphorylation (OXPHOS) Promotes the Formation and Growth of Melanoma Lung and Brain Metastases
Renato A. Guerrieri, Grant M. Fischer, David A. Kircher, Aron Y. Joon, Josué Cortez, Allie H. Grossmann, Courtney W. Hudgens, Debora Alejandra Ledesma, Rossana Lazcano, Christian Y. Beke Onana, Barbara G. Knighton, Swaminathan Kumar, Qianghua Hu, Y. N. Vashisht Gopal, Jennifer Leigh McQuade, , Michael A. Davies
This study shows that oxidative phosphorylation (OXPHOS) is critical for melanoma metastasis to the lungs and brain, based on analysis of human patients and mouse models.
bioRxiv · Jan 23, 2025 · PreprintCancer Biology