Alexander J. Lazar

This study identifies DSRCT-specific neogenes regulated by the EWS::WT1 fusion protein and shows their potential as biomarkers and therapeutic targets in desmoplastic small round cell tumors.

This study compares canine and human peripheral nerve sheath tumors, finding that H3K27me3 loss and H3K27ac gain drive tumor progression in both species.

This study identifies two epigenetically distinct cell states in leiomyosarcoma using single-nucleus multiome sequencing and spatial transcriptomics, linking them to clinical outcomes and therapeutic vulnerabilities.

This study uses single-nucleus multiome sequencing and spatial transcriptomics to analyze liposarcoma subtypes, revealing distinct cellular states, immune features, and gene regulatory circuits.

This study uses spatial transcriptomics to analyze AML in both medullary and extramedullary tissues, revealing inflammation and trans-differentiation states.

This study shows ATRX loss in sarcomas correlates with poor outcomes and identifies TEAD inhibition as a potential therapy for ATRX-deficient tumors.

MorphLink identifies disease-related morphological-molecular interplays in multi-modal spatial omics data by linking interpretable morphological features with molecular measurements.

This study shows that oxidative phosphorylation (OXPHOS) is critical for melanoma metastasis to the lungs and brain, based on analysis of human patients and mouse models.