Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewed
Non-cell-autonomous mechanisms of tumor initiation and relapse by chromosomal instability
Simona Jole Anna Lafirenze, Bastiaan van Gerwen, Ajit I. Quirindongo…·Geert J.P.L. Kops
This study shows that chromosomal instability (CIN) can both promote and suppress tumor formation depending on its level, with high CIN acting non-cell-autonomously to drive tumor relapse.
DOI 10.1073/pnas.2531095123