Geert J.P.L. Kops

This paper introduces Waldo, a genetic barcoding system that links live-cell imaging phenotypes to single-cell sequencing data for the same cells.

This study shows that chromosomal instability (CIN) can both promote and suppress tumor formation depending on its level, with high CIN acting non-cell-autonomously to drive tumor relapse.

The paper shows that polyploid cells in intestinal regeneration are cleared through mitotic errors despite centrosome clustering, leading to rapid loss of faulty lineages.

This study shows that RSV forms condensates by pre-assembling replication centers within viral particles, explaining infection heterogeneity and enabling efficient replication without requiring pre-existing condensates.

This study identifies 16 kinetochore proteins in Tetrahymena thermophila, revealing both conventional and unconventional components that contribute to its unique kinetochore structure.

The paper identifies binary karyotypes as universally selected in cancers and yeast, showing lower TP53 mutation rates and increased fitness compared to other aneuploid karyotypes.

This study shows p53 inactivation is not universally linked to aneuploidy but is associated with increased chromosome loss in cancer.

The paper identifies a universal scaling law for mitotic spindles across eukaryotes, showing metaphase plate width scales with genome size following a power law with an exponent of ~1/3, driven by chromosome crowding.

This study examines the evolutionary dynamics of peritoneal metastases in colorectal cancer, finding they are more heterogeneous than liver metastases but less diverse than locoregional metastases.

The paper identifies biallelic mutations in CENATAC as a cause of constitutional aneuploidy by disrupting minor intron splicing and causing chromosome segregation errors.

The paper identifies a conserved motif cassette in BubR1 essential for the spindle checkpoint through phylogenomics and functional analysis.