Structural basis of Ty1 integrase tethering on RNA polymerase III for targeted DNA integration
Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, Joël Acker, Juan Reguera, Pascale Lesage, Carlos Fernández‐Tornero
This study determines the structural basis of Ty1 integrase interaction with RNA polymerase III, revealing key residues and conformational changes that facilitate targeted DNA integration.
Nature Communications · Mar 28, 2023Peer-reviewedMolecular Biology