Author

Pascale Lesage

Centre National de la Recherche ScientifiqueORCID 0000-0002-4221-8038Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Noé PalmiciD· 3 shared Amandine BonnetiD· 2 shared Amna Asif-LaidiniD· 2 shared Christine Conesa· 2 shared Joël AckeriD· 2 shared Adrián Plaza-PeguerolesiD· 1 shared Beatrice Capuzzi· 1 shared Benoı̂t PalancadeiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMolecular Biology

Noé PalmicORCID

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3 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedMar 28, 2023

Structural basis of Ty1 integrase tethering on RNA polymerase III for targeted DNA integration

Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin…·Carlos Fernández‐Tornero

This study determines the structural basis of Ty1 integrase interaction with RNA polymerase III, revealing key residues and conformational changes that facilitate targeted DNA integration.

10 citations

yeastexperimental assay

𝕏 PostBluesky

Molecular BiologyPLoS GeneticsPeer-reviewedNov 1, 2021

A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription

Amandine Bonnet, Carole Chaput, Noé Palmic…·Pascale Lesage

The paper shows that the Nup84 complex restricts Ty retrotransposon transcription in yeast by tethering Ulp1 to NPCs, preventing retrotransposition.

9 citations

yeastDNA methylation

𝕏 PostBluesky

Molecular BiologybioRxivPreprintDec 18, 2019

The Ty1 integrase nuclear localization signal is necessary and sufficient for retrotransposon targeting to tRNA genes

Amna Asif-Laidin, Christine Conesa, Amandine Bonnet…·Pascale Lesage

The paper shows that the IN1 bNLS is necessary and sufficient for retrotransposon integration into Pol III-transcribed genes.

DOI 10.1101/2019.12.18.879569

yeastexperimental assay

𝕏 PostBluesky