Disturbed repolarisation-relaxation coupling during acute ischaemia permits systolic mechano-arrhythmogenesis.
Breanne Ashleigh Cameron, Peter Baumeister, Tarek Lawen, Sara A. Rafferty, Behzad Taeb, Matthew R. Stoyek, Joachim Greiner, Ilija Uzelac, Flavio H. Fenton, Rémi Peyronnet, Peter Karl Kohl, Thomas Alexander Quinn
This study shows that disturbed repolarisation-relaxation coupling during acute ischaemia increases systolic mechano-arrhythmogenesis, which can be mitigated by restoring coupling or targeting calcium, TRPA1, or ROS.
Circulation Research · Jun 2, 2025Peer-reviewedPhysiology