Matthew R. Stoyek

This study compares the defibrillation efficacy of different channelrhodopsins in human cardiac tissue using simulations, finding that ion selectivity affects arrhythmia termination mechanisms and success.

This study shows that disturbed repolarisation-relaxation coupling during acute ischaemia increases systolic mechano-arrhythmogenesis, which can be mitigated by restoring coupling or targeting calcium, TRPA1, or ROS.

This study shows that TRPA1 activation and disrupted repolarisation-relaxation coupling during systole contribute to mechano-arrhythmogenesis in ischaemic conditions.