Prostaglandin E2 Reverses Myofibroblast Differentiation in Eosinophilic Esophagitis
Ryugo Teranishi, Takefumi Itami, Masaru Sasaki, Kanak V. Kennedy, Yusen Zhou, Chizoba N. Umeweni, Emily A. McMillan, Archana Anandakrishnan, Reness Lee, Diya Dhakal, Hailey Golden, Grace Davis, Tatiana A. Karakasheva, Mark Mahon, Bella V. Peterson, , Amanda B. Muir
This study shows that Prostaglandin E2 reverses myofibroblast differentiation in EoE via the cAMP/YAP/THBS-1 pathway, suggesting it as a potential treatment for fibrostenotic EoE.
bioRxiv · Jan 29, 2026 · PreprintCell Biology