Mark Mahon

Systemic Analysis of Patient Derived Esophageal Epithelial Organoid Model Reveals Cell State Heterogeneity and Conservation of Differentiation Hierarchy

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

Prostaglandin E2 Reverses Myofibroblast Differentiation in Eosinophilic Esophagitis

This study shows that Prostaglandin E2 reverses myofibroblast differentiation in EoE via the cAMP/YAP/THBS-1 pathway, suggesting it as a potential treatment for fibrostenotic EoE.

FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.