Author

Takefumi Itami

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

Amanda B. MuiriD· 3 shared Kelly A. WhelaniD· 3 shared Mark MahoniD· 3 shared Ryugo TeranishiiD· 3 shared Tatiana A. KarakashevaiD· 3 shared Yusen ZhouiD· 3 shared Alyssa BaccarellaiD· 2 shared Benjamin J. WilkinsiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Amanda B. MuirORCID

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Author profile →

3 papers

Recent·Most cited

Systemic Analysis of Patient Derived Esophageal Epithelial Organoid Model Reveals Cell State Heterogeneity and Conservation of Differentiation Hierarchy

Alyssa Baccarella, Yusen Zhou, Tatiana A. Karakasheva, Ravi Gautam, Megha Lal, Jarad Beers, Zoe Mrozek, Ann Semeao, Leena Mirchandani, Ryugo Teranishi, Takefumi Itami, Kanak Kennedy, Mark Mahon, Ezuka Ogbolu, Judith R. Kelsen, , Melanie A. Ruffner

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

bioRxiv · Oct 30, 2026 · PreprintCell Biology

Prostaglandin E2 Reverses Myofibroblast Differentiation in Eosinophilic Esophagitis

Ryugo Teranishi, Takefumi Itami, Masaru Sasaki, Kanak V. Kennedy, Yusen Zhou, Chizoba N. Umeweni, Emily A. McMillan, Archana Anandakrishnan, Reness Lee, Diya Dhakal, Hailey Golden, Grace Davis, Tatiana A. Karakasheva, Mark Mahon, Bella V. Peterson, , Amanda B. Muir

This study shows that Prostaglandin E2 reverses myofibroblast differentiation in EoE via the cAMP/YAP/THBS-1 pathway, suggesting it as a potential treatment for fibrostenotic EoE.

bioRxiv · Jan 29, 2026 · PreprintCell Biology

FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis

Masaru Sasaki, Joshua X. Wang, Yusen Zhou, Kanak V. Kennedy, Ryugo Teranishi, Takefumi Itami, Satoshi Ishikawa, Takeo Hara, Heidi Winters, Emily A. McMillan, Mark Mahon, Hailey Golden, Diya Dhakal, Alyssa Baccarella, Chizoba N. Umeweni, , Amanda B. Muir

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.

bioRxiv · May 25, 2025 · PreprintMolecular Biology