Yusen Zhou

Systemic Analysis of Patient Derived Esophageal Epithelial Organoid Model Reveals Cell State Heterogeneity and Conservation of Differentiation Hierarchy

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

The Human Gut Cell Atlas v1.0: A Unified, Community-Built Reference of Cellular Diversity Across the Gut

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

Prostaglandin E2 Reverses Myofibroblast Differentiation in Eosinophilic Esophagitis

This study shows that Prostaglandin E2 reverses myofibroblast differentiation in EoE via the cAMP/YAP/THBS-1 pathway, suggesting it as a potential treatment for fibrostenotic EoE.

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn's disease

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

GlycoEnzDB: A database of enzymes involved in human glycosylation

GlycoEnzDB curates and presents human glycoenzyme data, linking enzyme functions, pathways, and expression data with external resources and AI-generated descriptions.

FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.

A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR)

This paper extends Linear Code to represent reaction rules in glycobiology, aiming to improve consistency and interoperability in glycan synthesis models.