DNA-PKcs governs LAT-dependent signaling in CD4+ and CD8+ T cells
Randall R Rainwater, Ana Clara P. Azevedo‐Pouly, Zachary J. Waldrip, Belle H. Hicks, Nicholas A. Callais, Brian S. Koss, Aaron J. Storey, Lyle J. Burdine, Marie Burdine
This study shows DNA-PKcs interacts with LAT at the immune synapse, phosphorylates specific serines, and is essential for T cell function in tumor control and graft rejection.
bioRxiv · Mar 6, 2025 · PreprintImmunology