Author

Brian S. Koss

La Jolla Institute for ImmunologyORCID 0000-0003-0155-4809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron J. StoreyiD· 1 shared Alexander MonelliD· 1 shared Allison CafferataiD· 1 shared Amir FerryiD· 1 shared Ana Clara P. Azevedo‐PoulyiD· 1 shared Ananda W. GoldrathiD· 1 shared Angelica E. RockiD· 1 shared Belle H. Hicks· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Aaron J. StoreyORCID

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2 papers

Recent·Most cited

ImmunologyCellPeer-reviewedNov 1, 2025

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function

Nicole E. Scharping, Xuezhen Ge, Maria I. Matias…·Ananda W. Goldrath

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

11 citationstop 5%

humanproteomics

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ImmunologybioRxivPreprintMar 6, 2025

DNA-PKcs governs LAT-dependent signaling in CD4+ and CD8+ T cells

Randall R Rainwater, Ana Clara P. Azevedo‐Pouly, Zachary J. Waldrip…·Marie Burdine

This study shows DNA-PKcs interacts with LAT at the immune synapse, phosphorylates specific serines, and is essential for T cell function in tumor control and graft rejection.

DOI 10.1101/2025.03.06.641745

mouseexperimental assay

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