A simplified hybrid capture approach retains high specificity and enables PCR-free workflow
Adeline Mah, Xiaodong Qi, Junhua Zhao, Kelly N. Wiseman, Laure Edoli, Kyle S. Metcalfe, Kyle Donohoe, Micah T. Ojeda, Sophie Billings, Juan Moreno, Marina McCowin, Ben Krajacich, Kevin Green, Ramkrishna Adhikary, Andrew M. Boddicker, , Michael J. R. Previte
This paper introduces a simplified hybrid capture method that eliminates PCR and bead-based steps while maintaining specificity and improving variant calling.
BMC Genomics · Sep 2, 2025Peer-reviewedGenomics