Xiaodong Qi

Cytos MPS integrates CRISPR guide identity, morphology, transcriptomics, and protein data to reveal multimodal phenotypes from perturbations.

The paper introduces a platform that directly sequences 3'UTRs and guide RNAs in fixed cells alongside protein abundance and morphology, enabling CRISPR screening in lung cancer cells.

This paper introduces a simplified hybrid capture method that eliminates PCR and bead-based steps while maintaining specificity and improving variant calling.

The paper demonstrates that AVITI and Illumina sequencing technologies equally capture sRNA and csRNA libraries from human, cattle, and bison, revealing inaccuracies in genome annotations and highlighting the need for small RNA sequencing in livestock.