Cancer BiologybioRxivPreprint
Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation
Kamila Burdova, Hongbin Yang, Roberta Faedda…·Vincenzo D’Angiolella
The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.
DOI 10.1101/509810