Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation
Kamila Burdova, Hongbin Yang, Roberta Faedda, Samuel Hume, Daniel Ebner, Benedikt M Kessler, Iolanda Vendrell, David H Drewry, Carrow I Wells, Stephanie B Hatch, Vincenzo D’Angiolella
The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.
bioRxiv · Jan 2, 2019 · PreprintCancer Biology