Vincenzo D’Angiolella

The paper identifies a p53-FBXO44-RAD18 axis that limits mutagenesis by terminating translesion DNA synthesis after replication stress.

This study identifies FBXO42 as a regulator of PP4 phosphatase activity, showing its role in controlling cellular processes through ubiquitination of PP4.

The paper identifies how neomorphic KBTBD4 mutations and the drug UM171 recruit HDAC1/2 complexes through structural mimicry, revealing a common mechanism for their degradation.

This study identifies how KBTBD4 cancer mutations drive neomorphic interactions with HDAC1/2, leading to CoREST degradation and tumor growth, and shows potential therapeutic strategies.

This paper determines the crystal structure of KLHL3 in complex with a WNK3 peptide, revealing structural features and phosphorylation-dependent regulation of WNK3 binding.

The paper determines the crystal structure of the KLHL20-DAPK1 complex, revealing the molecular basis of DAPK1 recruitment to the KLHL20 E3 ligase and suggesting a novel target for PROTAC-based drug design.

The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.