Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes
Adam Majcher, Par Bjorklund, Aleš Holfeld, Aneta Čináková, Alina Zurcher, Ermanno Malagola, Elkhan Yusifov, Sofia Kakava, Jerome Robert, Jennifer Härdfeldt, Katarína Hadová, Eva Kráľová, Bodo Levkau, Alaa Othman, Giuseppe Lauria, , Thorsten Hornemann
This study identifies metabolic origins of neurotoxic 1-deoxySL in T2D through proteomics, lipidomics, and metabolomics analyses in human and rodent models.
bioRxiv · Apr 25, 2025 · PreprintNeuroscience