Ermanno Malagola

Endocrine Neural Interactions Regulate Antral CCK2R+ Stem Cells in Gastric Inflammation and Preneoplasia

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1.

This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.

Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression

The paper identifies Dclk1-expressing cells in the pancreas and reveals their role in inhibiting pancreatic tumor progression through a tuft cell-ILC2 axis.

Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity

This study identifies VLC fatty acids as mediators of 1-deoxySL toxicity through mitochondrial dysfunction and BAX-dependent apoptosis.

Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes

This study identifies metabolic origins of neurotoxic 1-deoxySL in T2D through proteomics, lipidomics, and metabolomics analyses in human and rodent models.

Nociceptive neurons interact directly with gastric cancer cells via a CGRP/Ramp1 axis to promote tumor progression

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.