Author

Aleš Holfeld

ETH ZurichORCID 0000-0003-0775-8634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam Majcher· 1 shared Alaa OthmaniD· 1 shared Alina Zurcher· 1 shared Alison K. GillinghamiD· 1 shared Aneta Čináková· 1 shared Basavraj KhanppnavariD· 1 shared Bengt Belgard· 1 shared Bo AngeliniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Adam Majcher

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes

Adam Majcher, Par Bjorklund, Aleš Holfeld, Aneta Čináková, Alina Zurcher, Ermanno Malagola, Elkhan Yusifov, Sofia Kakava, Jerome Robert, Jennifer Härdfeldt, Katarína Hadová, Eva Kráľová, Bodo Levkau, Alaa Othman, Giuseppe Lauria, , Thorsten Hornemann

This study identifies metabolic origins of neurotoxic 1-deoxySL in T2D through proteomics, lipidomics, and metabolomics analyses in human and rodent models.

bioRxiv · Apr 25, 2025 · PreprintNeuroscience

Systematic identification of structure-specific protein-protein interactions

Aleš Holfeld, Dina Schuster, Fabian Sesterhenn, Alison K. Gillingham, Patrick Stalder, Walther Haenseler, Inigo Barrio‐Hernandez, Dhiman Ghosh, Jane Vowles, Sally A. Cowley, Luise Nagel, Basavraj Khanppnavar, Tetiana Serdiuk, Pedro Beltrão, Volodymyr M. Korkhov, , Paola Picotti

This study systematically identifies structure-specific protein-protein interactions using LiP-MS, demonstrating its application to alpha-synuclein in Parkinson's disease.

Molecular Systems Biology · May 3, 2024Peer-reviewedSystems Biology