Author

Sofia Kakava

University of ZurichORCID 0000-0003-3315-2361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alaa OthmaniD· 2 shared Arnold von EckardsteiniD· 2 shared Eveline SchlumpfiD· 2 shared Jérôme RobertiD· 2 shared Adam Majcher· 1 shared Aleš HolfeldiD· 1 shared Alina Zurcher· 1 shared Aneta Čináková· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Alaa OthmanORCID

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3 papers

Recent·Most cited

Cell BiologyAtherosclerosisPeer-reviewedAug 25, 2026

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion

Grigorios Panteloglou, Jérôme Robert, Marieke Smit…·Arnold von Eckardstein

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

DOI 10.1016/j.atherosclerosis.2026.121887

humanmouse

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 23, 2025

Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain.

Sofia Kakava, Mary Gonzalez Melo, Wai Hang Cheng…·Jérôme Robert

The paper investigates how high-density lipoproteins (HDL) cross the blood-brain barrier, showing that LDLR and apoE composition determine HDL entry and brain localization.

DOI 10.1101/2025.05.23.655828

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 25, 2025

Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes

Adam Majcher, Par Bjorklund, Aleš Holfeld…·Thorsten Hornemann

This study identifies metabolic origins of neurotoxic 1-deoxySL in T2D through proteomics, lipidomics, and metabolomics analyses in human and rodent models.

1 citation

humanmouse

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