Alaa Othman

The paper identifies cell type-specific lipid and protein compositions of apoE lipoproteins secreted by different brain cell types and found in cerebrospinal fluid.

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

qg generates reproducible, configuration-driven acquisition queues for mass spectrometry with QC control and vendor-specific file output.

This study identifies SPTLC3's role in integrating bile acid-FXR signaling with sphingolipid remodeling in MASLD, showing its dysregulation in human liver and association with disease.

This paper shows that PKA-dependent phosphorylation drives stress granule maturation during prolonged starvation, delaying disassembly and promoting cell survival.

This study identifies metabolic origins of neurotoxic 1-deoxySL in T2D through proteomics, lipidomics, and metabolomics analyses in human and rodent models.

The paper shows that stress-induced changes in extracellular vesicles from mice can alter sperm and embryo transcriptomes, leading to metabolic issues in offspring.

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

The paper profiles the metabolome of 180 cancer cell lines and identifies two major metabolic types linked to epithelial-mesenchymal transition (EMT).

This study shows that RNA nucleotide repeats cause mitochondrial dysfunction and ribosome-associated quality control issues in C. elegans, with Coenzyme Q supplementation rescuing the defects.

This study identifies a DEGS1 mutation causing sphingolipid metabolism defects, leading to neurological disorders and suggests dietary intervention as a potential treatment.

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.