Author

Adam Majcher

University Hospital Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Thorsten HornemanniD· 4 shared Elkhan YusifoviD· 3 shared Ermanno MalagolaiD· 2 shared Maftuna Shamshiddinova· 2 shared Par BjorklundiD· 2 shared Alaa OthmaniD· 1 shared Aleš HolfeldiD· 1 shared Alina Zurcher· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiochemistry

Thorsten HornemannORCID

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Author profile →

4 papers

Recent·Most cited

CYP4F2-mediated ω-hydroxylation of 1-deoxysphingolipids reveals a new hepatic detoxification pathway

Adam Majcher, Essa M. Saied, Zoltán Kutalik, Maftuna Shamshiddinova, Andreas J. Hülsmeier, Par Bjorklund, Elkhan Yusifov, Irina Alecu, Christoph Arenz, Thorsten Hornemann

This study identifies CYP4F2 as a key enzyme mediating ω-hydroxylation of 1-deoxySLs, revealing a new hepatic detoxification pathway that reduces their cytotoxicity.

bioRxiv · May 14, 2026 · PreprintBiochemistry

Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity

Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin, Ermanno Malagola, Péter Horváth, Jinmei Li, Maftuna Shamshiddinova, Gai Zhibo, Raghvendra Dubey, Timothy R. Peterson, Sofía Rodriguez-Gallardo, Kuniyoshi Shimizu, 武士原山, Thorsten Hornemann

This study identifies VLC fatty acids as mediators of 1-deoxySL toxicity through mitochondrial dysfunction and BAX-dependent apoptosis.

bioRxiv · May 13, 2025 · PreprintBiochemistry

Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes

Adam Majcher, Par Bjorklund, Aleš Holfeld, Aneta Čináková, Alina Zurcher, Ermanno Malagola, Elkhan Yusifov, Sofia Kakava, Jerome Robert, Jennifer Härdfeldt, Katarína Hadová, Eva Kráľová, Bodo Levkau, Alaa Othman, Giuseppe Lauria, , Thorsten Hornemann

This study identifies metabolic origins of neurotoxic 1-deoxySL in T2D through proteomics, lipidomics, and metabolomics analyses in human and rodent models.

bioRxiv · Apr 25, 2025 · PreprintNeuroscience

Disrupted Sphingosine-1-Phosphate Homeostasis Drives Nephrotoxicity in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome (SPLIS)

Adam Majcher, Kathrin Buder, Ranjha Khan, Julie Deane Saba, Thorsten Hornemann

This paper investigates SPLIS, showing that S1P accumulation in SPL-deficient cells leads to nephrotoxicity, which can be mitigated by Fasudil.

bioRxiv · Jan 21, 2025 · PreprintPhysiology