A Rare T-Cell Factor 4 Lineage-negative Epithelial Stem Cell Supports Wound Repair and APC-deletion-induced Colon Tumorigenesis
Annika V. Thorpe, Tim Mosbruger, Stephanie J. Georges, Olivia M. Crowley, Thérèse M.F. Tuohy, Brian K. Dalley, Benjamin D. Bice, Andrew K. Fuller, Julio Hidalgo, Christopher D. Green, Saher Sue Hammoud, Melinda L. Angus-Hill
The paper identifies a rare Tcf4 lineage-negative stem cell population in the colon that contributes to wound repair and colon tumorigenesis when Apc is deleted.
bioRxiv · Mar 18, 2026 · PreprintCell Biology