Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer
Abbie S. Ireland, Daniel A Xie, Sarah B. Hawgood, Margaret W. Barbier, Lisa Y. Zuo, Benjamin E Hanna, Scarlett Lucas-Randolph, Darren R. Tyson, Benjamin L. Witt, Ramaswamy Govindan, Afshin Dowlati, Justin C. Moser, Anish Thomas, Sonam Puri, Charles M. Rudin, , Trudy G. Oliver
The paper identifies basal cells as the origin of neuroendocrine-tuft-like tumors in SCLC, revealing lineage plasticity and transcriptional states that mirror human cancer and normal cell injury responses.
Nature · Sep 17, 2025Peer-reviewedCancer Biology