Ramaswamy Govindan

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer

The paper identifies basal cells as the origin of neuroendocrine-tuft-like tumors in SCLC, revealing lineage plasticity and transcriptional states that mirror human cancer and normal cell injury responses.

RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer

RegTools identifies splice-associated variants in cancer by integrating genomic and transcriptomic data across 9,000 tumor samples, discovering 235,778 splicing events.

A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

The paper presents a pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis of tumor regions and xenograft-transplant lymphoproliferative disorder prediction.

Identification of community-consensus clinically relevant variants and development of single molecule molecular inversion probes using the CIViC database

The paper designs single molecule molecular inversion probes targeting clinically relevant variants using the CIViC database, demonstrating high sensitivity and discovering missed variants in cancer samples.