A role for LGI1 in regulating pain sensitivity.
Adham Farah, Ryan Patel, Piotr Popławski, Benjamin J Wastie, Mandy Tseng, Allison M Barry, Omar Daifallah, Dubb, Akash, Ivan Paul, Hoi lao Cheng, Faisal Feroz, Yuhe Su, Marva Chan, Hanns Ulrich Zeilhofer, Theodore J Price, , John M. Dawes
This study investigates the role of LGI1 in pain regulation using mouse models, finding that LGI1 ablation in spinal neurons exacerbates neuropathic pain behaviors, suggesting a spinal mechanism for its role in pain sensitivity.
bioRxiv · Sep 13, 2023Neuroscience