Samuel R. Daniels

This study identifies a non-canonical metabolic pathway in cancer cells that uses β-hydroxybutyrate for fatty acid synthesis, supporting tumor growth under lipid-limited conditions.

The paper shows lipid-starved cancer cells are more sensitive to ferroptosis due to increased PUFA trafficking into phospholipids, challenging the assumption that PUFA levels directly determine ferroptosis susceptibility.

This study shows that -synuclein aggregation disrupts cortico-amygdala connectivity, leading to social behavior deficits in synucleinopathies, and that restoring this connection can rescue the behavior.

This study investigates how alpha-synuclein aggregation in the basolateral amygdala affects glutamatergic transmission, finding that it selectively disrupts cortico-BLA synapses.

This study identifies reduced thalamic excitation to motor cortical pyramidal tract neurons in a mouse model of parkinsonism, mediated by NMDA receptor overactivation and reversible via chemogenetic suppression of basal ganglia outputs.

This study shows that motor cortical pyramidal neurons in Parkinsonism exhibit cell-type-specific decreases in intrinsic excitability due to impaired ion channel function.