High-throughput glioblastoma-neurovascular assembloids model blood-tumor barrier disruption, tumor reprogramming and therapeutic efficacy
Pei Zhuang, Shuai Gao, Benjamin Scott, Yibo Jia, Wei-Min Meng, Rui Yin, Xinyu Nie, Soniya Tamhankar, Sean P. Palecek, Ludovica Gaiaschi, Jorge L. Jimenez-Macias, Shuichi Mizuno, Sean Edward Lawler, Eric Shusta, Martine L.M. Lamfers, , Choi‐Fong Cho
This paper develops a high-throughput BTB assembloid model to study glioblastoma-neurovascular interactions and therapeutic responses, finding that BTB disruption correlates with increased tumor invasiveness and drug resistance.
bioRxiv · Nov 11, 2024 · PreprintBioengineering