Author

Choi‐Fong Cho

Brigham and Women's HospitalORCID 0000-0003-1473-9773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Jorge L. Jimenez-MaciasiD· 2 shared Sean Edward LawleriD· 2 shared Alexander S. BrodskyiD· 1 shared Andrea SchmidtiD· 1 shared Ayush BharatiiD· 1 shared Benjamin Scott· 1 shared Bin WuiD· 1 shared Bogdan I. FedelesiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Jorge L. Jimenez-MaciasORCID

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2 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedFeb 26, 2025

Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM

Jorge L. Jimenez-Macias, Philippa C. Vaughn-Beaucaire, Ayush Bharati…·Sean Edward Lawler

This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.

24 citationstop 1%

humanspatial transcriptomics

𝕏 PostBluesky

BioengineeringbioRxivPreprintNov 11, 2024

High-throughput glioblastoma-neurovascular assembloids model blood-tumor barrier disruption, tumor reprogramming and therapeutic efficacy

Pei Zhuang, Shuai Gao, Benjamin Scott…·Choi‐Fong Cho

This paper develops a high-throughput BTB assembloid model to study glioblastoma-neurovascular interactions and therapeutic responses, finding that BTB disruption correlates with increased tumor invasiveness and drug resistance.

1 citation

humanscRNA-seq

𝕏 PostBluesky