Fengfeng Bei

OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies

This study shows that OPTN dysfunction leads to neuroinflammation and RGC death in glaucoma, independent of IOP, and identifies OPTN-NPY signaling as a potential therapeutic target.

High-throughput glioblastoma-neurovascular assembloids model blood-tumor barrier disruption, tumor reprogramming and therapeutic efficacy

This paper develops a high-throughput BTB assembloid model to study glioblastoma-neurovascular interactions and therapeutic responses, finding that BTB disruption correlates with increased tumor invasiveness and drug resistance.

A blood-brain-barrier penetrant AAV gene therapy rescues neurological deficits in mucolipidosis IV mice.