High-Efficiency Pharmacogenetic Ablation of Oligodendrocyte Progenitor Cells in the Adult Mouse CNS
Yao Lulu Xing, Jasmine Poh, Bernard H.A. Chuang, Kaveh Moradi, Stanislaw Mitew, William David Richardson, Trevor John Kilpatrick, Yasuyuki Osanai, Tobias D. Merson
This paper develops a pharmacogenetic model to ablate oligodendrocyte progenitor cells (OPCs) in adult mice, achieving 98.6% depletion and revealing compensatory mechanisms from V-SVZ-derived NPCs.
Cell Reports Methods · Feb 1, 2023Peer-reviewedNeuroscience