Author

Tobias D. Merson

Australian Regenerative Medicine InstituteORCID 0000-0002-7246-3608Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Organism:non-human primate· 1 Assay:snRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Yao Lulu XingiD· 3 shared Jasmine Poh· 2 shared Kaveh Moradi· 2 shared Stanislaw MitewiD· 2 shared Yasuyuki OsanaiiD· 2 shared Amali CoorayiD· 1 shared Anthony G. BoghdadiiD· 1 shared Benjamin CaoiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Yao Lulu XingORCID

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4 papers

Recent·Most cited

HB-EGF and EGF infusion following CNS demyelination mitigates age-related decline in regeneration of oligodendrocytes from neural precursor cells originating in the ventricular-subventricular zone

Kaveh Moradi, Stanislaw Mitew, Yao Lulu Xing, Tobias D. Merson

This study shows that infusing HB-EGF and EGF into aged mice improves oligodendrocyte regeneration from NPCs after CNS demyelination.

bioRxiv · Feb 26, 2024 · PreprintNeuroscience

High-Efficiency Pharmacogenetic Ablation of Oligodendrocyte Progenitor Cells in the Adult Mouse CNS

Yao Lulu Xing, Jasmine Poh, Bernard H.A. Chuang, Kaveh Moradi, Stanislaw Mitew, William David Richardson, Trevor John Kilpatrick, Yasuyuki Osanai, Tobias D. Merson

This paper develops a pharmacogenetic model to ablate oligodendrocyte progenitor cells (OPCs) in adult mice, achieving 98.6% depletion and revealing compensatory mechanisms from V-SVZ-derived NPCs.

Cell Reports Methods · Feb 1, 2023Peer-reviewedNeuroscience

5' transgenes drive leaky expression of 3' transgenes in inducible bicistronic vectors

Yasuyuki Osanai, Yao Lulu Xing, Kenta Kobayashi, Jihane Homman‐Ludiye, Amali Cooray, Jasmine Poh, Nobuhiko Ohno, Tobias D. Merson

The paper investigates leaky expression of 3' transgenes in bicistronic vectors and shows that 5' transgenes can drive promoter-like activity, leading to Cre-independent expression.

bioRxiv · Apr 23, 2022 · PreprintMolecular Biology

Primate-specific response of astrocytes to stroke limits peripheral macrophage infiltration

Anthony G. Boghdadi, Joshua M. Spurrier, Leon Teo, Mingfeng Li, Mario Škarica, Benjamin Cao, William Chin Kwan, Tobias D. Merson, Susan K. Nilsson, Nenad Šestan, Stephen M. Strittmatter, James A. Bourne

The paper identifies primate-specific astrocyte responses to stroke, showing NogoA limits macrophage infiltration and suggests therapeutic targeting.

bioRxiv · May 8, 2020 · PreprintNeuroscience