Yasuyuki Osanai

The paper describes methods to visualize and analyze the morphology of individual oligodendrocytes in mouse white matter using genetic labeling and immunostaining techniques.

This study shows that GABA signaling in the optic nerve mediates experience-dependent myelination, with binocular deprivation having less impact than monocular deprivation.

The paper shows that oligodendrocytes selectively myelinate Purkinje cell axons in the mouse cerebellar white matter, with this preference established during development.

This paper develops a pharmacogenetic model to ablate oligodendrocyte progenitor cells (OPCs) in adult mice, achieving 98.6% depletion and revealing compensatory mechanisms from V-SVZ-derived NPCs.

The paper investigates leaky expression of 3' transgenes in bicistronic vectors and shows that 5' transgenes can drive promoter-like activity, leading to Cre-independent expression.

This study reveals that individual interfascicular oligodendrocytes selectively myelinate distant axons with consistent thicknesses and that adjacent sheaths show correlated thicknesses.