Early onset of Ca2+ waves and synchronization in multicellular clusters facilitate focal arrhythmogenesis in human heart failure
Darya Kazakova, Michael A. Colman, Ankit Pradhan, Lukas Gudaitis, Luka Nys, Bert Cools, Filip Rega, Bert Vandenberk, Cesare M. Terracciano, H. Llewelyn Roderick, Karin R. Sipido, Eef Dries
This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.
bioRxiv · May 2, 2025 · PreprintPhysiology