PhysiologybioRxivPreprint
Early onset of Ca2+ waves and synchronization in multicellular clusters facilitate focal arrhythmogenesis in human heart failure
Darya Kazakova, Michael A. Colman, Ankit Pradhan…·Eef Dries
This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.