Filip Rega

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

The paper identifies MGST1 as a key antioxidant gene in cardiac fibroblasts, showing its loss in heart failure increases oxidative stress and ferroptosis susceptibility.

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.

Early onset of Ca2+ waves and synchronization in multicellular clusters facilitate focal arrhythmogenesis in human heart failure

This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.