USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma
Pablo Táboas, Enrique Blanco, Estela Prada, Tobias Faehling, María Sánchez-Jiménez, Carla Ríos-Astorch, Merce Baulenas‐Farres, Berta Estrada-Bes, Xenia Cuadros-Hernández, Silvia Mateo‐Lozano, Soledad Gómez‐González, Sara Pérez‐Jaume, Cinzia Emilia Lavarino, Thomas G. P. Grünewald, Florencia Cidre‐Aranaz, , Sara Sánchez-Molina
This study identifies USP7 as a critical regulator of PAX3::FOXO1 enhancers in FP-RMS and shows its inhibition reduces tumor growth.
bioRxiv · Jun 8, 2026 · PreprintCancer Biology