Integration of artificial intelligence and high-content screening enabled identification of drugs for long-term treatment of cerebral cavernous malformation disease
Eduardo Frías-Anaya, Helios Gallego-Gutiérrez, Cassandra Bui, Janeth O. Birrueta, Jeffrey D. Steinberg, Ingrid R. Niesman, Brendan Gongol, Brina Nguyen, Aaryaman Sawhney, Zaida Mizushima, Nyle Connolly, Bethan S. Kilpatrick, Issam A. Awad, Hemal H. Patel, JoAnn Trejo, , Miguel Alejandro Lopez‐Ramirez
This paper identifies metformin as a potential drug for long-term treatment of cerebral cavernous malformations using AI, high-throughput screening, and animal models.
bioRxiv · Dec 11, 2025 · PreprintPathology