Targeting CDC42 with CASIN Reprograms Cell-Type-Specific Transcriptomes and MAPK-Driven Transcription Factor Networks in the Aging Brain
Jaehyun LeeBae, Verena Bopp, Bettina Moehrle, Julia K. Kühlwein, Veselin Grozdanov, Martin Kiechle, Benjamin Mayer, Hartmut Geiger, Karin M. Danzer
The paper shows that CASIN inhibits CDC42, reversing PD-related transcriptional changes and affecting MAPK and PI3K/AKT pathways in an aging mouse model.
bioRxiv · Aug 14, 2026 · PreprintNeuroscience