Jeffrey J. Molldrem

The paper develops a biophysical model to predict T cell receptor specificity for viral and tumor antigens using structural data and sequence-based clustering.

This study identifies molecular features of MRD progression in MDS using single-cell multi-omic profiling, revealing dynamic evolutionary processes and immunoevasive mechanisms.

This study shows that 2ME2 treatment reduces GVHD mortality and morbidity while maintaining GVL activity in mice.

The paper shows that CuS nanoparticle-mediated photothermolysis of ovarian cancer cells enhances dendritic cell activation and T cell expansion compared to ionizing radiation.

This study identifies ASXL1 truncating mutations as a driver of leukemic resistance to T cell attack and proposes EZH2 inhibition as a therapeutic strategy to overcome this resistance.

This study examines how allogeneic stem cell transplant affects subclonal evolution in chronic lymphocytic leukemia, identifying cellular homogeneity as a biomarker for immune response.