Author

Xiaohong Leng

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-8775-2621Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Bijal Thakkar· 1 shared Catherine J. WuiD· 1 shared Dustin McCurryiD· 1 shared Elham AziziiD· 1 shared Emerie E DansoniD· 1 shared Jaehyun Lee· 1 shared Jeffrey J. MolldremiD· 1 shared Jerome RitziD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Bijal Thakkar

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1 paper

Recent·Most cited

ASXL1 truncating mutations drive leukemic resistance to T cell attack

Dustin McCurry, Zhongqi Ge, Jaehyun Lee, Rishi Pasumarthi, Xiaohong Leng, Thomas Köhnke, Oren Pasvolsky, Pranaya Raparla, Vinhkhang N. Nguyen, Katie Maurer, Shuqiang Li, Kenneth J. Livak, Emerie E Danson, Bijal Thakkar, Elham Azizi, , Pavan Bachireddy

This study identifies ASXL1 truncating mutations as a driver of leukemic resistance to T cell attack and proposes EZH2 inhibition as a therapeutic strategy to overcome this resistance.

bioRxiv · May 29, 2025 · PreprintCancer Biology