RPRM (Reprimo) triggers SCF(FBXW11)-mediated DNA-PKcs degradation to block non-homologous end joining and radiosensitize tumors
Zhaojun Steven Li, Yarui Zhang, Binghua Tang, Shuning Xu, Zhiyan Zhu, Jingdong Wang, Guomin Ou, Jinsheng Hong, Minglian Qiu, Hongying Yang
This paper identifies RPRM as a tumor suppressor that inhibits NHEJ repair by promoting DNA-PKcs degradation, enhancing tumor radiosensitivity.
bioRxiv · Dec 16, 2025 · PreprintCancer Biology