Cancer BiologybioRxivPreprint
RPRM (Reprimo) triggers SCF(FBXW11)-mediated DNA-PKcs degradation to block non-homologous end joining and radiosensitize tumors
Zhaojun Steven Li, Yarui Zhang, Binghua Tang…·Hongying Yang
This paper identifies RPRM as a tumor suppressor that inhibits NHEJ repair by promoting DNA-PKcs degradation, enhancing tumor radiosensitivity.
DOI 10.64898/2025.12.14.694167