Author

Yarui Zhang

First Affiliated Hospital of Fujian Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Hongying YangiD· 2 shared Jingdong Wang· 2 shared Binghua Tang· 1 shared Guomin Ou· 1 shared Jin WangiD· 1 shared Jinsheng HongiD· 1 shared Minglian Qiu· 1 shared Shuning Xu· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Hongying YangORCID

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2 papers

Recent·Most cited

RPRM (Reprimo) triggers SCF(FBXW11)-mediated DNA-PKcs degradation to block non-homologous end joining and radiosensitize tumors

Zhaojun Steven Li, Yarui Zhang, Binghua Tang, Shuning Xu, Zhiyan Zhu, Jingdong Wang, Guomin Ou, Jinsheng Hong, Minglian Qiu, Hongying Yang

This paper identifies RPRM as a tumor suppressor that inhibits NHEJ repair by promoting DNA-PKcs degradation, enhancing tumor radiosensitivity.

bioRxiv · Dec 16, 2025 · PreprintCancer Biology

RPRM as a potential preventive and therapeutic target for radiation-induced brain injury via multiple mechanisms

Zhujing Ye, Jin Wang, Wenyu Shi, Zhou Zhou, Yarui Zhang, Jingdong Wang, Hongying Yang

This study shows that RPRM deletion reduces radiation-induced brain injury in mice by targeting multiple mechanisms including DNA damage, neurogenesis, inflammation, and microglial activation.

bioRxiv · Aug 3, 2023 · PreprintNeuroscience