Hyper-responsiveness of cancer stem cells to microenvironmental cues controls metastasis and therapy response through YAP/TAZ/TEAD
Binwu Tang, Jacob Minin, Victoria Gonzalez, Zoya Khan, Yuval Raviv, Yu-an Yang, Christine P. Carney, Zachary Millman, Daniel Grun, Cristiana M. Pineda, Alina Sharma, Dominic Esposito, Hualong Yan, Jing Li Huang, Andy D. Tran, , Lalage M. Wakefield
This study shows cancer stem cells (CSCs) have distinct population dynamics and are hyper-responsive to microenvironmental cues, which regulate metastasis and therapy response via the YAP/TAZ/TEAD pathway.
bioRxiv · Mar 13, 2025 · PreprintCancer Biology