Dominic Esposito

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving the Disassembly of the Autoinhibited BRAF State

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

Hyper-responsiveness of cancer stem cells to microenvironmental cues controls metastasis and therapy response through YAP/TAZ/TEAD

This study shows cancer stem cells (CSCs) have distinct population dynamics and are hyper-responsive to microenvironmental cues, which regulate metastasis and therapy response via the YAP/TAZ/TEAD pathway.

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.

Modified E. coli strains enhance baculovirus production by elimination of aberrant transposition events

The paper describes modified E. coli strains that block native Tn7 attachment sites to reduce contamination from non-recombinant baculovirus production.