Long-read sequencing of single cell-derived melanoma subclones reveals divergent and parallel genomic and epigenomic evolutionary trajectories
Yuelin Liu, Anton Goretsky, Ayşe Gökçe Keşküş, Salem Malikić, Tanveer Ahmad, E. Michael Gertz, Farid Rashidi Mehrabadi, Michael C. Kelly, Maria Hernandez, Charlie Seibert, Juan Manuel Caravaca, Kayla Kline, Yongmei Zhao, Ying Wu, Biraj Shrestha, , Mikhail Kolmogorov
The paper uses long-read sequencing to analyze genomic and epigenomic changes in melanoma subclones, revealing parallel evolutionary paths and lineage-specific methylation patterns.
bioRxiv · Aug 28, 2025 · PreprintGenomics